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KMID : 0043320080310111497
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Archives of Pharmacal Research
2008 Volume.31 No. 11 p.1497 ~ p.1507
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Enhanced Dissolution of Ibuprofen Using Solid Dispersion with Poloxamer 407
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Yong Chul-Soon
Choi Han-Gon
Woo Jong-Soo
Sung Jun-Ho
Kim Young-Ran
Oh Dong-Hoon
Bhandari Krishna Hari
Newa Madhuri
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Abstract
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To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, and in-vitro ibuprofen release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and Cmax, and a significant decrease in Tmax over pure ibuprofen. Comparison of the enhanced solubility, dissolution, AUC, and Cmax of ibuprofen from different poloxamers suggested that the preparation of ibuprofen SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its solubility, dissolution and absorption rate.
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KEYWORD
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Ibuprofen, Solid dispersions, Poloxamers, Solubility, Dissolution, Bioavailability
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